Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.

نویسندگان

  • Dafydd R Owen
  • John K Walker
  • E Jon Jacobsen
  • John N Freskos
  • Robert O Hughes
  • David L Brown
  • Andrew S Bell
  • David G Brown
  • Christopher Phillips
  • Brent V Mischke
  • John M Molyneaux
  • Yvette M Fobian
  • Steve E Heasley
  • Joseph B Moon
  • William C Stallings
  • D Joseph Rogier
  • David N A Fox
  • Michael J Palmer
  • Tracy Ringer
  • Margarita Rodriquez-Lens
  • Jerry W Cubbage
  • Radhika M Blevis-Bal
  • Alan G Benson
  • Brad A Acker
  • Todd M Maddux
  • Michael B Tollefson
  • Brian R Bond
  • Alan Macinnes
  • Yung Yu
چکیده

A new class of potent and selective PDE5 inhibitors is disclosed. Guided by X-ray crystallographic data, optimization of an HTS lead led to the discovery of a series of 2-aryl, (N8)-alkyl substituted-6-aminosubstituted pyrido[3,2b]pyrazinones which show potent inhibition of the PDE5 enzyme. Synthetic details and some structure-activity relationships are also presented.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 19 15  شماره 

صفحات  -

تاریخ انتشار 2009